948022-46-6

Basic information

• Product Name: (R)-2-(4-(4-chloro-3-fluorophenyl)-2-methylpiperazin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide
• Synonyms: (R)-2-(4-(4-chloro-3-fluorophenyl)-2-methylpiperazin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide
• CAS NO: 948022-46-6
• Molecular Weight: 432.839
• Mol File: 948022-46-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-(4-chloro-3-fluorophenyl)-2-methylpiperazin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-(4-chloro-3-fluorophenyl)-2-methylpiperazin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide(948022-46-6)
• EPA Substance Registry System: (R)-2-(4-(4-chloro-3-fluorophenyl)-2-methylpiperazin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide(948022-46-6)

Safety Data

• Hazardous Substances Data: 948022-46-6(Hazardous Substances Data)

Upstream product

• 22876-17-1 6-amino-1,3-benzoxazol-2-(3H)-one 
• 1095543-77-3 (3R)-1-(4-chloro-3-fluoro-phenyl)-3-methyl-piperazine 

Relevant articles and documents

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization

Selective N-methyl-D-aspartate receptor subunit 2B (NR2B) antagonists show potential as analgesic drugs, and do not cause side effects associated with non-selective N-methyl-D-aspartate (NMDA) antagonists. Using a scaffold-hopping approach, we previously identified isoxazole derivative 4 as a potent selective NR2B antagonist. In this study, further scaffold hopping of isoxazole derivative 4 and optimization of its pharmacokinetic profile led to the discovery of the orally bioavailable compound 6v. In a rat study of analgesia, 6v demonstrated analgesic effects against neuropathic pain.