94844-02-7

Basic information

• Product Name: 1-Propanol, 2,2-dimethyl-3-(phenylamino)-
• CAS NO: 94844-02-7
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Mol File: 94844-02-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Propanol, 2,2-dimethyl-3-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 2,2-dimethyl-3-(phenylamino)-(94844-02-7)
• EPA Substance Registry System: 1-Propanol, 2,2-dimethyl-3-(phenylamino)-(94844-02-7)

Safety Data

• Hazardous Substances Data: 94844-02-7(Hazardous Substances Data)

Usage

Type of alcohol

Tertiary

Structure

Branched, with a methyl group attached to the second carbon atom

Appearance

Clear, colorless

Odor

Characteristic alcohol-like

Usage

Solvent in various industries, production of pharmaceuticals, perfumes, and other organic compounds

Safety precautions

Harmful if ingested or inhaled, causes irritation to skin and eyes

Upstream product

• 72708-59-9 2,2-dimethyl-3-oxo-3-(phenylamino)propanoic acid 
• 7507-43-9 ethyl 2,2-dimethyl-3-oxo-3-(phenylamino)propanoate 
• 597-31-9 2,2-dimethyl-3-hydroxypropionaldehyde 
• 62-53-3 aniline 
• 64244-87-7 2-chlorocarbonyl-2-methylpropanoic acid ethyl ester 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 595-46-0 2,2-dimethylmalonic acid 

Downstream Products

• 133732-95-3 2-(Dimethylamino)-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 94844-00-5 2-(dimethylamino)-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 112565-62-5 N-(3-Hydroxy-2,2-dimethyl-propyl)-4-methyl-N-phenyl-benzenesulfonamide 
• 112565-68-1 3,3-dimethyl-1,2,3,4-tetrahydro-1-p-tolylsulphonylquinoline 
• 112565-67-0 3,3-dimethyl-1,2-dihydro-1-p-tolylsulphonylquinolin-4(3H)-one 
• 112565-66-9 3-(N-phenyl-p-toluenesulphonyl-3-amino)-2,2-dimethylpropionic acid 
• 103752-09-6 2-methoxy-2-oxo-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 103752-15-4 2-methoxy-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 112565-64-7 2,2-dimethyl-N-phenyl-3-p-tolylsulphonyloxypropionamide 
• 112565-63-6 N-(2,2-dimethyl-3-p-tolylsulphonyloxypropyl)-N-phenyltoluene-p-sulphonamide 
• 133732-94-2 2,3-Diphenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane 
• 103752-14-3 2-chloro-3-phenyl-5,5-dimethyl-1,3,2-oxazaphosphorinane 

Relevant articles and documents

Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles

Silicon-containing compounds have been largely ignored in drug design and development, despite their potential to improve not only the potency but also the physicochemical and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties of drug-like candidates because of the unique characteristics of silicon. This deficiency is in large part attributable to a lack of general methods for synthesizing diverse organosilicon structures. Accordingly, a new building block strategy has been developed that diverges from traditional approaches to incorporation of silicon into drug candidates. Flexible, multi-gram-scale syntheses of silicon-containing tetrahydroquinoline and tetrahydroisoquinoline building blocks are described, along with methods by which diversely functionalized silicon-containing nitrogen heterocycles can be rapidly built using common reactions optimized to accommodate the properties of silicon. Furthermore, to better clarify the liabilities and advantages of silicon incorporation, select compounds and their carbon analogues were challenged in ADMET-focused biological studies.

X-ray and 1H NMR Studies of the Conformational Equilibria of 2-Z-3-Phenyl-1,3,2-oxazaphosphorinanes. Steric and Stereoelectronic Influences on the Unexpected Axial Preferences of Me2N and MeNH Substituents on Three-Coordinate Phosphorus

A series of 2-Z-3-phenyl-1,3,2-oxazaphosphorinanes 7-14 (Z = MeO, (CF3)2CHO, Ph, MeNH, and Me2N) containing three-coordinate phosphorus was prepared.The conformations of the six-membered rings were investigated by 1H and 31P NMR spectroscopy and X-ray cry

CONFORMATIONS OF SATURATED SIX-MEMBERED-RING PHOSPHOROUS HETEROCYCLES. CHAIR-CHAIR EQUILIBRIA FOR CYCLOPHOSPHAMIDE, THE 5,5-DIMETHYL DERIVATIVE, AND RELATED 1,3,2-OXAZAPHOSPHORINANES. RELATIVE CONFORMATIONAL ENERGIES OF NITROGEN MUSTARD AND OTHER R2<

A series of 5,5-dimethyl-3-R-2-oxo-2-Z-1,3,2-oxazaphosphorinanes (1, R= H, Z= Me2N; 2, R= H, Z= Et2N; 3, R= H, Z= i-Pr2N; 4, R= H, Z= N(CH2CH2Cl)2; 5, R= Ph,Z= Me2N) has been prepared, and their conformations have been studied by 1H NMR at 300 MHz.The pos