94860-72-7

Basic information

• Product Name: 3-hydroxy-1-phenyl-2-(2-phenylhydrazono)propan-1-one
• Synonyms: 3-hydroxy-1-phenyl-2-(2-phenylhydrazono)propan-1-one
• CAS NO: 94860-72-7
• Molecular Weight: 254.288
• Mol File: 94860-72-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-1-phenyl-2-(2-phenylhydrazono)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-1-phenyl-2-(2-phenylhydrazono)propan-1-one(94860-72-7)
• EPA Substance Registry System: 3-hydroxy-1-phenyl-2-(2-phenylhydrazono)propan-1-one(94860-72-7)

Safety Data

• Hazardous Substances Data: 94860-72-7(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 50-00-0 formaldehyd 
• 5335-28-4 phenyl-glyoxal-2-phenylhydrazone 
• 15823-87-7 phenylglyoxal-2-(Z)-phenylhydrazone 

Downstream Products

• 1055324-54-3 1-[6-benzoyl-2-phenyl-2,3-dihydropyridazin-4-yl]ethanone 
• 1265801-99-7 1-(6-benzoyl-5-hydroxy-2-phenyl-2,3,4,5-tetrahydropyridazin-4-yl)ethanone 
• 1265802-02-5 3-benzoyl-1,6-diphenyl-1,2-dihydropyrrolo[3,4-c]pyridazine-5,7-dione 
• 119853-19-9 1-phenyl-hexane-1,2,4,5-tetraone-2,4-bis-phenylhydrazone 
• 103269-18-7 1,5-diphenyl-pentane-1,2,4,5-tetraone-2-(4-nitro-phenylhydrazone)-4-phenylhydrazone 
• 3306-06-7 (1RS,2SR)-2-amino-1-phenyl-propane-1,3-diol 
• 14838-15-4 u-2-amino-1-phenylpropan-1-ol 
• 121849-33-0 1,1'-diphenyl-3,3'-piperazine-1,4-diyl-bis-propane-1,2-dione 2,2'-bis-phenylhydrazone 
• 110378-55-7 3-morpholin-4-yl-1-phenyl-propane-1,2-dione 2-phenylhydrazone 
• 744-25-2 2-Phenylhydrazono-3-piperidinopropiophenon 

Relevant articles and documents

Improved synthesis of 2-arylhydrazono-3-hydroxy-1-propanones and their utility in efficient synthesis of pyridazine derivatives

Reaction of 2-arylhydrazono-1-phenylethanones 2a-c with formaldehyde either in presence of montmorillonite K10 or by simply stirring in methanol and TEA leads to selective synthesis of 2-arylhydrazono-3-hydroxy-1-phenylpropan-1-one derivatives 3a-c in high yield. Heating 1a with N-phenylmaleimide in DPE/DABCO using microwave irradiation for 5 minutes at 200 °C results in a 73% yield of pyrrolo[3, 4-c]pyridazine 8. Compounds 2a-c react with benzylidenemalononitriles 9a or ethyl 2-cyanocinnamate 9b in refluxing ethanol and piperidine or β-chitosan to yield new pyridazine derivatives 10a-f which are converted into pyridazinones 11a-c upon reflux in acetic/hydrochloric acids mixture. ARKAT-USA, Inc.