948902-44-1

Basic information

• Product Name: CF₃O₃S^(1-)*C₁₄H₁₈BrN₄O₂S⁽¹⁺⁾
• Synonyms: CF₃O₃S^(1-)*C₁₄H₁₈BrN₄O₂S⁽¹⁺⁾
• CAS NO: 948902-44-1
• Molecular Weight: 535.363
• Mol File: 948902-44-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: CF₃O₃S^(1-)*C₁₄H₁₈BrN₄O₂S⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: CF₃O₃S^(1-)*C₁₄H₁₈BrN₄O₂S⁽¹⁺⁾(948902-44-1)
• EPA Substance Registry System: CF₃O₃S^(1-)*C₁₄H₁₈BrN₄O₂S⁽¹⁺⁾(948902-44-1)

Safety Data

• Hazardous Substances Data: 948902-44-1(Hazardous Substances Data)

Upstream product

• 948902-42-9 C₁₃H₁₅BrN₄O₂S 
• 333-27-7 methyl trifluoromethanesulfonate 

Downstream Products

• 948902-45-2 C₁₆H₂₄BrN₃O₄S 

Relevant articles and documents

MMP-13-SELECTIVE INHIBITOR

Since it is thought that if the activity of MMP-13 can be inhibited, this will largely contribute to improvement or prevention of progession of pathological states, particularly, osteoarthritis (OA), resulting from or associated with the MMP-13 activity, the development of MMP-13 inhibitors is anticipated. There are provided a compound represented by the general formula (I): wherein R1 is optionally substituted aryl etc. Z is C1-C5 alkylene which may be substituted and may be interrupted with a substituent selected from Substituent group a etc.; A is the formula: (R6 and R7 are each independently halogen, lower alkyl etc.; m and n are each independently 0, 1, or 2); R2 is a hydrogen atom, optionally substituted lower alkyl etc.; R3 is a hydrogen atom, optionally substituted lower alkyl etc.; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxy, lower alkyloxy etc.), or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof, and a pharmaceutical composition containing it as an active ingredient, which has the MMP-13 inhibiting activity.