948913-18-6

Basic information

• Product Name: 7-[3-methyl-3-(4-methyl-piperazin-1-yl)-but-1-ynyl]-6-nitro-quinazolin-4-ol
• Synonyms: 7-[3-methyl-3-(4-methyl-piperazin-1-yl)-but-1-ynyl]-6-nitro-quinazolin-4-ol
• CAS NO: 948913-18-6
• Molecular Weight: 355.396
• Mol File: 948913-18-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-[3-methyl-3-(4-methyl-piperazin-1-yl)-but-1-ynyl]-6-nitro-quinazolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[3-methyl-3-(4-methyl-piperazin-1-yl)-but-1-ynyl]-6-nitro-quinazolin-4-ol(948913-18-6)
• EPA Substance Registry System: 7-[3-methyl-3-(4-methyl-piperazin-1-yl)-but-1-ynyl]-6-nitro-quinazolin-4-ol(948913-18-6)

Safety Data

• Hazardous Substances Data: 948913-18-6(Hazardous Substances Data)

Upstream product

• 169194-80-3 1-methyl-4-(2-methylbut-3-yn-2-yl)piperazine 
• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 

Relevant articles and documents

PROCESSES FOR SYNTHESIZING 7-ALKYNYL-4-AMINOQUINAZOLINES AND A RELATED INTERMEDIATE

A process for synthesizing 7-alkynyl-4-aminoquinazolines from 7-haloquinazolines is disclosed. In one specific synthesis, 4-[N-3-chloro-4-fluorophenyl)]-7- [3-methyl-3-(4-methyl-l-piperazinyl)-l- butynyl]-6-[N-inethyl acrylamide] quinazoline is prepared from 7-chloro-6-nitro-3H-quinazolin-4-one. Also disclosed is an intermediate useful in the syntheses of 7-alkynyl-4-ammoquinaozolines and a process for making the intermediate. The 7-alkynyl-4-aminoquinaozolines prepared by processes of the invention are useful as pharmaceutically active compounds.