949149-60-4

Basic information

• Product Name: (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate
• Synonyms: (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate
• CAS NO: 949149-60-4
• Molecular Weight: 323.392
• Mol File: 949149-60-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate(949149-60-4)
• EPA Substance Registry System: (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate(949149-60-4)

Safety Data

• Hazardous Substances Data: 949149-60-4(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 617-52-7 Dimethyl itakonate 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 192214-00-9 (S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid 
• 573704-57-1 (+)-(S)-3-carbamidopyrrolidine-1-carboxylic acid benzyl ester 
• 72580-53-1 (S)-(+)-3-pyrrolidinecarboxylic acid 
• 949149-64-8 (3S)-benzyl-1-[(R)-1-phenylethyl]pyrrolidine-3-carboxylate 
• 949149-62-6 (S)-benzyl-1-((R)-1-phenylethyl)-5-thioxopyrrolidine-3-carboxylate 

Relevant articles and documents

A rapid and convenient synthesis of β-proline

A short, reliable, and cheap synthesis of both enantiomers of β-proline, an efficient organocatalyst and an important building block in medicinal chemistry, has been developed in four steps (overall yield: 72%) from the diasteromeric adducts of methyl itaconate and (R)-α-methylbenzylamine. The key step involves the chemoselective reduction of a lactam group in the presence of a benzyl ester.