94938-03-1

Basic information

• Product Name: 1-METHYL-2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE
• Synonyms: 1-METHYL-2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE
• CAS NO: 94938-03-1
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• Mol File: 94938-03-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-METHYL-2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE(94938-03-1)
• EPA Substance Registry System: 1-METHYL-2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE(94938-03-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 94938-03-1(Hazardous Substances Data)

Usage

General Description

1-Methyl-2-phenyl-1H-imidazole-5-carbaldehyde is a chemical compound that belongs to the imidazole family. It is a yellow solid with a molecular formula of C11H10N2O. 1-METHYL-2-PHENYL-1H-IMIDAZOLE-5-CARBALDEHYDE is used in organic chemistry as a reagent and intermediate in the synthesis of various pharmaceuticals and agrochemicals. It also has potential applications in the field of material science and drug discovery. 1-Methyl-2-phenyl-1H-imidazole-5-carbaldehyde is known for its ability to participate in various chemical reactions, making it a valuable tool in the development of new compounds and materials.

Upstream product

• 616-38-6 carbonic acid dimethyl ester 
• 68282-47-3 2-phenyl-1H-imidazole-4-carbaldehyde 
• 161670-65-1 1-methyl-2-phenyl-5-trifluoroacetylimidazole 
• 161670-80-0 ethyl 1-methyl-2-phenyl-1H-imidazole-5-carboxylate 
• 14119-99-4 4-trifluoroacetyl-3-methyl-2-phenyl-1,3-oxazol-3-ium-5-olate 
• 2568-34-5 N-benzoyl-N-methylglycine 
• 74-88-4 methyl iodide 
• 161670-81-1 (1-methyl-2-phenyl-1H-imidazol-5-yl)methanol 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF

A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

Convenient synthesis of 5-trifluoroacetylated imidazoles by ring transformation of mesoionic 1,3-oxazolium-5-olates

Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1), obtained from the reaction of N-acyl-N-alkylglycines (2) with trifluoroacetic anhydride, react with amidines to give 5-trifluoroacetylimidazoles (3) in moderate yield. The novel ring transformations of 1 into 3 occur via an initial attack of amidines on the C-2 position of the ring.

A Novel Ring Transformation of Mesoionic 1,3-Oxazolium-5-olates into 5-Trifluoroacetylated and 5-Perfluoroacylated Imidazoles by Reaction with Amidines

Treatment of mesoionic 1,3-oxazolium-5-olates with amidines causes a novel ring transformation affording 5-trifluoroacetyl- and 5-perfluoroacyl-imidazoles in moderate yields.