949586-03-2Relevant articles and documents
Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants
Loiseleur, Olivier,Ritson, Dougal,Nina, Mafalda,Crowley, Patrick,Wagner, Trixie,Hanessian, Stephen
, p. 6353 - 6363 (2008/02/10)
(Chemical Equation Presented) The importance of functional group orientations and the integrity of the bicyclic perhydrofuran core of malayamycin A and two equally active N-nucleoside analogues as fungicides were investigated. Two analogues 10 and 11, representing a THP-truncated and a bicyclic aza-variant, were synthesized and found to be inactive. Molecular dynamics studies on malayamycin A and analogues were performed to highlight the importance of properly orientating the urea and methyl ether groups.