949890-75-9 Usage
Description
(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid is a chiral chemical compound with the molecular formula C18H25NO4. It is a derivative of 3-methylhexanoic acid, featuring an additional benzyloxycarbonylamino-methyl group. The (S)-enantiomer of this compound is the biologically active form, making it a significant constituent in the development of pharmaceuticals, particularly those targeting the central nervous system. Its unique chemical structure and properties render it a valuable asset in medicinal chemistry, with ongoing research exploring its potential applications further.
Uses
Used in Pharmaceutical Synthesis:
(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid serves as a crucial precursor in the synthesis of various pharmaceuticals. Its unique structure allows it to be a building block for developing drugs that can effectively target the central nervous system, addressing a wide range of neurological disorders and conditions.
Used in Cancer Therapy Research:
(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid has garnered interest for its potential use in cancer therapy. The biological activity of the (S)-enantiomer suggests that it may play a role in the development of novel treatments for cancer. Ongoing research is focused on understanding its mechanisms of action and its potential to be incorporated into therapeutic strategies against various types of cancer.
Used in Medicinal Chemistry:
(-)-(S)-3-(benzyloxycarbonylamino-methyl)-5-methyl-hexanoic acid is a valuable tool in medicinal chemistry. Its unique properties and structure make it an ideal candidate for further exploration and development in the creation of new drugs and therapies. Researchers are continuously investigating its potential applications to expand the horizons of medical treatments and improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 949890-75-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,9,8,9 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 949890-75:
(8*9)+(7*4)+(6*9)+(5*8)+(4*9)+(3*0)+(2*7)+(1*5)=249
249 % 10 = 9
So 949890-75-9 is a valid CAS Registry Number.
949890-75-9Relevant articles and documents
Preparation method for asymmetrical synthesis of pregabalin
-
, (2016/10/10)
The invention discloses a preparation method for asymmetric synthesis of pregabalin.The preparation method includes: using 3-isobutylglutaric anhydride as a starting raw material; under catalytic action of chiral thiourea ammonium salt, enabling the starting raw material to be in asymmetric alcoholysis with mercaptan to generate mercaptide; enabling mercaptide to react with diphenylphosphoryl azide and benzyl alcohol sequentially to generate benzyloxy carbonyl methyl mercaptide; obtaining pregabalin through hydrolysis and hydrogenation reduction.The synthetic method is adopted to synthesize pregabalin, asymmetric catalysis is adopted to synthesize a key intermediate, a chemical resolution reagent is not used, total yield is greater than 50%, and ee value is greater than 94%.The preparation method has the advantages of novel synthesis path, few steps, mild reaction condition and the like.
Synthesis, characterization and in vitro pharmacology of novel pregabalin derivatives
Horvat, ?tefica,Hamer?ak, Zdenko,Stipeti?, Irena,Jolas, Thierry
experimental part, p. 1447 - 1452 (2010/06/14)
A series of novel pregabalin derivatives were synthesized starting from N-protected pregabalin, different amino sugars, adamantylamine, serotonin and tryptamine. New compounds were spectroscopically characterized and in vitro tested on gabapentin receptor binding assay. The serotonin-pregabalin adduct showed significant binding effect and its IC50 value was determined.
