95-21-6 Usage
Description
2-Methylbenzoxazole, a member of the class of 1,3-benzoxazoles, is a clear colorless to yellow liquid with a burnt roast aroma. It is characterized by the presence of a methyl group at position 2 on the 1,3-benzoxazole structure. This organic compound exhibits a high strength odor, reminiscent of a tobacco type, and is recommended to be smelled in a 0.10% solution or less.
Uses
Used in Organic Synthesis:
2-Methylbenzoxazole is utilized as a key intermediate in the synthesis of various organic compounds, including bis-styryl dyes. Its unique chemical structure allows it to serve as a valuable building block in the development of new and innovative molecules.
Used in Pharmaceutical Industry:
In the field of medicine, 2-Methylbenzoxazole is employed as a precursor for the synthesis of pharmaceutical compounds. Its versatile chemical properties make it suitable for the development of new drugs and therapeutic agents.
Used in Fragrance Industry:
Due to its distinctive tobacco-like aroma, 2-Methylbenzoxazole is used as a fragrance ingredient in the perfumery and cosmetics industry. Its high strength odor makes it a valuable addition to various scent formulations.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 675, 1996 DOI: 10.1016/0040-4039(95)02240-6
Biochem/physiol Actions
Odor at 1.0%: Musty, nutty pecan, almond and pistachio-like, tobacco, vanilla-like with brown roasted burnt rubber and cooked rice-like nuances.Taste at 2.0ppm: Musty, nutty, vanilla and rice-like.
Check Digit Verification of cas no
The CAS Registry Mumber 95-21-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 95-21:
(4*9)+(3*5)+(2*2)+(1*1)=56
56 % 10 = 6
So 95-21-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NO/c1-6-9-7-4-2-3-5-8(7)10-6/h2-5H,1H3
95-21-6Relevant articles and documents
Disubstituted Ferrocenyl Iodo- And Chalcogenoalkynes as Chiral Halogen and Chalcogen Bond Donors
Aubert, Emmanuel,Cossu, Sergio,Mamane, Victor,Pale, Patrick,Peluso, Paola,Weiss, Robin,Wenger, Emmanuel
, p. 3936 - 3950 (2020)
Asymmetric catalysis based on halogen and chalcogen bonds (XB and ChB) is in its infancy, and the search for new chiral XB and ChB donors represents a crucial step toward its development. In this context, we designed and prepared new motifs containing three key substructures: namely, regions of electron charge density depletion centered on iodine and chalcogen atoms, the ethynyl functionality, and the planar chiral ferrocenyl platform. Nine ferrocenyl iodoalkynes were prepared as pure enantiomers by asymmetric synthesis. The XB donor property of racemic ferrocenyl iodoalkynes was demonstrated in solution in two benchmark reactions: the Ritter reaction and the benzoxazole synthesis from thioamides. In contrast, the ferrocenyl chalcogenoalkynes were far less active in these reactions. The potential of racemic and enantiopure ferrocenyl iodoalkynes as XB donors was also confirmed by X-ray diffraction analysis, showing I···C contacts between the electropositive σ-hole of the iodine atom and electron-rich πclouds for all crystal structures studied in the solid state.
Synthetic Applications of a New Magnetic Mesoporous Nanocomposite Catalyst Fe3O4@MCM-41@NH-SO3H
Pourhasan-Kisomi, Reyhaneh,Shirini, Farhad,Golshekan, Mostafa
, p. 166 - 175 (2021/04/09)
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Application of [PVP-SO3H] HSO4 as an Efficient Polymeric-Based Solid Acid Catalyst in the Synthesis of Some Benzimidazole Derivatives
Roudsari, Fatemeh Pakpour,Seddighi, Mohadeseh,Shirini, Farhad,Tajik, Hassan
, p. 1 - 14 (2020/07/27)
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