95043-81-5

Basic information

• Product Name: 5α-Androst-16-en-3β-ol, 17-iodo-
• Synonyms: 5α-Androst-16-en-3β-ol, 17-iodo-;(3S,5S,8R,9S,10S,13S,14S)-17-iodo-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS NO: 95043-81-5
• Molecular Formula: C₁₉H₂₉IO
• Molecular Weight: 400.33743
• Mol File: 95043-81-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5α-Androst-16-en-3β-ol, 17-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 5α-Androst-16-en-3β-ol, 17-iodo-(95043-81-5)
• EPA Substance Registry System: 5α-Androst-16-en-3β-ol, 17-iodo-(95043-81-5)

Safety Data

• Hazardous Substances Data: 95043-81-5(Hazardous Substances Data)

Upstream product

• 53-43-0 dehydroepiandrosterone 
• 481-29-8 Epiandrosterone 
• 1239-31-2 3β-acetoxy-5α-androstan-17-one 
• 10481-80-8 3β-hydroxy-17-hydrozone-5α-androstane 
• 10481-80-8 3β-hydroxy-5α-androstan-17-one hydrazone 

Downstream Products

• 7148-51-8 5α-androst-16-en-3β-ol 
• 219843-75-1 (3β,5α)-17-(3'-pyridinyl)androst-16-en-3-ol 
• 694438-95-4 (3β,5α)-17-phenylandrost-16-en-3-ol 
• 18339-16-7 5α-androst-16-en-3-one 
• 1153-51-1 3β-Hydroxy-androst-16-en 

Relevant articles and documents

Synthetic method of androst-16-en-3beta-ol

The invention discloses a synthetic method of androst-16-en-3beta-ol. According to the method, 17-iodoandrosta-16-en-3beta-ol is subjected to deiodination in an organic solvent under the protection ofargon under the action of alkali metal alkoxide to prepare androst-16-en-3beta-ol. The synthetic method is simple and convenient to operate, avoids the use of metallic sodium and lithium alkyl reagents, and has relatively mild conditions.

Abiraterone acetate reducing impurity and preparation method thereof

The invention discloses an abiraterone acetate reducing impurity and a preparation method thereof. The impurity is 17-(3-pyridyl) androstane-3 beta-acetoxyl. The preparation method of the impurity includes the steps: taking dehydroepiandrosterone as a starting material; performing catalytic hydrogenation by palladium carbon to obtain (3 beta)-3-hydroxy-17-sterone; performing reaction by hydrazine hydrate to obtain 17-hydrazono-androstane-3 beta-alcohol; performing iodine substitution to obtain 17-iodine-androstane-3 beta-alcohol; reacting the 17-iodine-androstane-3 beta-alcohol with borane reagents under palladium catalysis to obtain 17-(3-pyridyl) androstane-3 beta-alcohol; performing acetic anhydride acetylation to obtain the abiraterone acetate reducing impurity 17-(3-pyridyl) androstane-3 beta-acetoxyl.

Microbiological hydroxylation of some epoxy steroids by the fungus Mucor plumbeus

The preparation of epoxy steroids derived from testosterone, dehydroisoandrosterone and epiandrosterone using m-chloroperbenzoic acid and their biotransformation by the fungus Mucor plumbeus is described. The results reveal an effect of the epoxide on the biotransformation.