950725-15-2Relevant articles and documents
Fluorinated 1,3-benzothiazin-4-ones containing fluoroquinolone fragment
Nosova, Emiliya V.,Batanova, Olga A.,Mochulskaya, Nataliya N.,Charushin, Valery N.
, (2019)
[Figure not available: see fulltext.] We have developed an efficient synthetic approach to potential antibacterial agents with double mechanism of action through the combination of antibacterial fluoroquinolones with 1,3-benzothiazin-4-ones.
SYNTHESIS AND ANTITUBERCULAR EVALUATION OF FLUORINATED 2-CYCLOALKYLIMINO SUBSTITUTED 1,3-BENZOTHIAZIN-4-ONES
Nosova, Emiliya V.,Batanova, Olga A.,Lipunova, Galina N.,Kotovskaya, Svetlana K.,Slepukhin, Pavel A.,Kravchenko, Marionella A.,Charushin, Valery N.
, p. 69 - 77 (2019)
Novel fluorinated 2-substituted 1,3-benzothiazin-4-ones were obtained through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates, followed by cyclization of fluorobenzoyl-thioureas. Synthetic approaches to original 2-cycloalkylimino- and 2-carbonylpiperazino- substituted benzothiazinones, bearing different number of fluorine atoms in the benzene ring have been found. 2-Ethoxycarbonylpiperazino-5-fluoro-1,3-benzothiazin-4-one proved to exhibit a high tuberculostatic activity in vitro (MIC 0.7 microgram/mL), thus indicating that a search of biologically active compounds in this family of heterocycles appears to be a reasonable approach.
Synthesis, biological evaluation and docking study of 3-aroyl-1-(4- sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors
Mahdavi, Mohammad,Shirazi, Maryam Shahzad,Taherkhani, Raana,Saeedi, Mina,Alipour, Eskandar,Moghadam, Farshad Homayouni,Moradi, Alireza,Nadri, Hamid,Emami, Saeed,Firoozpour, Loghman,Shafiee, Abbas,Foroumadi, Alireza
, p. 308 - 313 (2014/06/24)
A series of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives containing sulfonamide moiety were designed and synthesized as 15-lipoxygenase (15-LOX) inhibitors. Most synthesized compounds showed potent activity against soybean 15-LOX with IC50
