951030-56-1

Basic information

• Product Name: 2-chloro-5-methylisonicotinic acid
• CAS NO: 951030-56-1
• Molecular Weight: 171.583
• Mol File: 951030-56-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-5-methylisonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-methylisonicotinic acid(951030-56-1)
• EPA Substance Registry System: 2-chloro-5-methylisonicotinic acid(951030-56-1)

Safety Data

• Hazardous Substances Data: 951030-56-1(Hazardous Substances Data)

Upstream product

• 60323-96-8 2-chloro-5-methyl-4-nitropyridine 1-oxide 
• 867279-13-8 4-bromo-2-chloro-5-methyl-pyridine 
• 124-38-9 carbon dioxide 
• 79055-62-2 2-chloro-5-methyl-pyridin-4-ylamine 

Downstream Products

• 787596-43-4 methyl 2-chloro-5-methylisonicotinate 

Relevant articles and documents

TETRAZOLE CONTAINING APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: (I) which inhibit the Apoptosis signal-regulating kinase 1 (ASK-l), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-l related disease. The invention also relates to methods of treating an ASK-l related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-l associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).