951127-27-8

Basic information

• Product Name: 1-(2,5-difluorophenyl)-2-nitroethanone
• Synonyms: 1-(2,5-difluorophenyl)-2-nitroethanone
• CAS NO: 951127-27-8
• Molecular Weight: 201.129
• Mol File: 951127-27-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-(2,5-difluorophenyl)-2-nitroethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,5-difluorophenyl)-2-nitroethanone(951127-27-8)
• EPA Substance Registry System: 1-(2,5-difluorophenyl)-2-nitroethanone(951127-27-8)

Safety Data

• Hazardous Substances Data: 951127-27-8(Hazardous Substances Data)

Usage

Physical state

Yellow solid at room temperature

Uses

a. Organic synthesis
b. Intermediate in the production of various compounds

Functional groups

a. Nitro group
b. Ketone group

Building block

Versatile for the synthesis of other organic molecules

Specific properties

Presence of difluorophenyl group

Applications

Useful in a variety of applications due to its specific properties

Safety precautions

Proper handling and safety measures should be observed when working with 1-(2,5-difluorophenyl)-2-nitroethanone

Upstream product

• 75-52-5 nitromethane 
• 35730-09-7 2,5-difluorobenzoyl chloride 
• 951127-26-7 1-(2,5-difluorophenyl)-2-nitroethanol 
• 2646-90-4 2,5-difluorobenzaldehyde 

Downstream Products

• 1601482-70-5 tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(5-(methylsulfonyl)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 1601479-72-4 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(5-(methylsulfonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)tetrahydro-2H-pyran-3-amine 
• 1601482-71-6 tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 1601479-75-7 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-amine 
• 1601482-72-7 tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-yl)carbamate 
• 1601479-76-8 (2R,3 S,5R)-2-(2,5-difluorophenyl)-5-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)tetrahydro-2H-pyran-3-amine 
• 1226781-87-8 tert-butyl {(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-yl}carbamate 
• 1226781-44-7 Omarigliptin 

Relevant articles and documents

AMINOTETRAHYDROPYRAN DERIVATIVE USED AS DIPEPTIDYL PEPTIDASE-IV INHIBITOR

Provided is an Aminotetrahydropyran derivative represented by general formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, and the use of the derivative to prepare a therapeutic agent, especially a dipeptidyl peptidase-IV inhibitor.

Inhibitor for dipeptidyl peptidase-IV

The invention provides an aminotetrahydropyran derivative with a general formula (I) as described in the specification, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof, a preparation method for the aminotetrahydropyran derivative, and a pharmaceutical composition containing the aminotetrahydropyran derivative. The aminotetrahydropyran derivative provided by the invention can inhibit the activity of dipeptidyl peptidase-IV(DPP-IV), and can be used for treatment of diseases related to dipeptidyl peptidase-IV, especially for treatment of diabetes.

Aminotetrahydropyran derivative used as dipeptidyl peptidase-IV inhibitor

The invention provides an aminotetrahydropyran derivative as shown in the general formula (I), pharmaceutically acceptable salt, hydrate, solvate and stereisomer of the derivative, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound can inhibit activity of dipeptidyl peptidase IV (DPP-IV) and can be used in treating diseases related to dipeptidyl peptidase IV.