951314-44-6

Basic information

• Product Name: N-(4-chlorophenyl)-2-hydroxynicotinamide
• Synonyms: N-(4-chlorophenyl)-2-hydroxynicotinamide
• CAS NO: 951314-44-6
• Molecular Weight: 248.669
• Mol File: 951314-44-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-2-hydroxynicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-2-hydroxynicotinamide(951314-44-6)
• EPA Substance Registry System: N-(4-chlorophenyl)-2-hydroxynicotinamide(951314-44-6)

Safety Data

• Hazardous Substances Data: 951314-44-6(Hazardous Substances Data)

Upstream product

• 609-71-2 2-hydroxy-3-carboxypyridine 
• 106-47-8 4-chloro-aniline 
• 10366-35-5 2-chloronicotinamide 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 1205-71-6 N-(4-chlorophenyl)aniline 

Relevant articles and documents

One-pot synthesis of n-aryl-nicotinamides and diarylamines based on a tunable smiles rearrangement

A one-pot Smiles rearrangement has been developed as a useful protocol for the straightforward synthesis of diverse N-aryl-nicotinamides. This method also provides chemoselective access toward diarylamines based on the different substitutions of the amide group. The potential application of the transformation is exemplified by the synthesis of an on-market succinate dehydrogenase inhibitor, boscalid. A substituent-mediated Smiles rearrangement to N-aryl-nicotinamides and diarylamines has been developed. In addition to the wide range of heterocyclic building blocks, the one-pot process also provides an efficient access to an on-market fungicide, boscalid.