95162-14-4

Basic information

• Product Name: 4-BROMO-1-TRITYL-1H-PYRAZOLE
• Synonyms: 4-BROMO-1-TRITYL-1H-PYRAZOLE;1H-Pyrazole,4-broMo-1-(triphenylMethyl)-;4-Bromo-1-tritylpyrazole;4-Bromo-1-trityl-1H-pyraziole;4-bromo-1-(triphenylmethyl)-1H-pyrazole
• CAS NO: 95162-14-4
• Molecular Formula: C₂₂H₁₇BrN₂
• Molecular Weight: 389.3
• Mol File: 95162-14-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 186-188℃ (hexane )
• Appearance: White/Powder
• Density: 1.27±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMO-1-TRITYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-TRITYL-1H-PYRAZOLE(95162-14-4)
• EPA Substance Registry System: 4-BROMO-1-TRITYL-1H-PYRAZOLE(95162-14-4)

Safety Data

• Hazardous Substances Data: 95162-14-4(Hazardous Substances Data)

Usage

General Description

4-BROMO-1-TRITYL-1H-PYRAZOLE is a chemical compound with the molecular formula C25H20BrN3. It is a pyrazole derivative that contains a trityl group and a bromine atom. 4-BROMO-1-TRITYL-1H-PYRAZOLE is often used as a building block in organic synthesis and medicinal chemistry research. It has been studied for its potential pharmaceutical applications, particularly as a ligand for metal-catalyzed reactions and as a precursor for various bioactive molecules. Its unique structure and reactivity make it a valuable tool for the development of new drugs and materials. However, due to its potential reactivity and toxicity, proper handling and safety precautions should be observed when working with 4-BROMO-1-TRITYL-1H-PYRAZOLE.

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 76-83-5 trityl chloride 

Downstream Products

• 191980-58-2 4-(4'-methoxyphenyl)-1-tritylpyrazole 
• 632297-68-8 methyl N-(tert-butyloxycarbonyl)-4-(1-trityl-1H-pyrazol-4-yl)-L-phenylalaninate 
• 863238-73-7 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triphenylmethyl)-1H-pyrazole 
• 936359-90-9 4-(4-fluoro-phenyl)-1-trityl-1H-pyrazole 
• 875554-08-8 methyl 1-trityl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS

The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.

Identification and Profiling of Hydantoins - A Novel Class of Potent Antimycobacterial DprE1 Inhibitors

Tuberculosis is the leading cause of death worldwide from infectious diseases. With the development of drug-resistant strains of Mycobacterium tuberculosis, there is an acute need for new medicines with novel modes of action. Herein, we report the discovery and profiling of a novel hydantoin-based family of antimycobacterial inhibitors of the decaprenylphospho-β-d-ribofuranose 2-oxidase (DprE1). In this study, we have prepared a library of more than a 100 compounds and evaluated them for their biological and physicochemical properties. The series is characterized by high enzymatic and whole-cell activity, low cytotoxicity, and a good overall physicochemical profile. In addition, we show that the series acts via reversible inhibition of the DprE1 enzyme. Overall, the novel compound family forms an attractive base for progression to further stages of optimization and may provide a promising drug candidate in the future.

Rhodium/chiral diene complexes in the catalytic asymmetric arylation of β-pyrazol-1-yl acrylates

The asymmetric conjugate addition of arylboronic acids to substituted and unsubstituted β-pyrazol-1-yl (E)-tert-butyl acrylates 4 catalyzed by 5 mol % of the Rh(I)/diene 2a catalyst provided the corresponding addition products in 44-98% yield and 91->99.5