951771-70-3Relevant articles and documents
Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved pk profile
Carcache, David,Vranesic, Ivo,Blanz, Joachim,Desrayaud, Sandrine,Fendt, Markus,Glatthar, Ralf
, p. 58 - 62 (2011/04/22)
A focused chemical optimization effort of compound 1 based on metabolite elucidation is described, resulting in 15i, a highly potent and selective mGlu5 receptor antagonist with an improved pharmacokinetic profile compared to 1. Characterization of 15i in