951784-65-9Relevant articles and documents
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding
Menichincheri, Maria,Albanese, Clara,Alli, Cristina,Ballinari, Dario,Bargiotti, Alberto,Caldarelli, Marina,Ciavolella, Antonella,Cirla, Alessandra,Colombo, Maristella,Colotta, Francesco,Croci, Valter,Dalessio, Roberto,Danello, Matteo,Ermoli, Antonella,Fiorentini, Francesco,Forte, Barbara,Galvani, Arturo,Giordano, Patrizia,Isacchi, Antonella,Martina, Katia,Molinari, Antonio,Moll, Jürgen K.,Montagnoli, Alessia,Orsini, Paolo,Orzi, Fabrizio,Pesenti, Enrico,Pillan, Antonio,Roletto, Fulvia,Scolaro, Alessandra,Tatò, Marco,Tibolla, Marcellino,Valsasina, Barbara,Varasi, Mario,Vianello, Paola,Volpi, Daniele,Santocanale, Corrado,Vanotti, Ermes
experimental part, p. 7296 - 7315 (2011/01/12)
Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53 independent apoptosis in tumor cells while reversibly arresting cell cycle progression in prima
