952151-43-8

Basic information

• Product Name: 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one
• Synonyms: 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one
• CAS NO: 952151-43-8
• Molecular Weight: 429.421
• Mol File: 952151-43-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one(952151-43-8)
• EPA Substance Registry System: 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one(952151-43-8)

Safety Data

• Hazardous Substances Data: 952151-43-8(Hazardous Substances Data)

Upstream product

• 952151-42-7 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 60456-26-0 (R)-glycidyl butyrate 
• 952151-38-1 5-benzyl-2-(tert-butyl) 1,2,5-oxadiazepane-2,5-dicarboxylate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 952151-41-6 5-(2,6-difluoro-4-nitrophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 66684-58-0 3,4,5-trifluoronitrobenzene 

Downstream Products

• 952151-44-9 C₂₀H₂₇F₂N₃O₈S 
• 952151-45-0 5(R)-(azidomethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 952151-48-3 5(S)-(acetylaminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 1138149-96-8 5(S)-(thioacetylaminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 1443005-59-1 O-methyl (S)-N-(3-(4-(1-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylthiocarbamate 
• 952152-87-3 O-methyl (S)-N-(3-(4-([1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylthiocarbamate 
• 1443005-63-7 5(R)-3-(4-(2-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one 
• 1138149-60-6 5(R)-3-(4-(2-[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one 
• 1443005-71-7 5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 952151-50-7 (S)-N-((3-(3,5-difluoro-4-(2-(hydroxyacetyl)[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 1138150-01-2 (S)-N-((3-(3,5-difluoro-4-(2-(hydroxyacetyl)[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)thioacetamide 
• 1254784-79-6 (S)-N-((3-(3,5-difluoro-4-(2-(hydroxyacetyl)[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-O-methylthiocarbamate 
• 1138149-61-7 5(R)-3-(4-(2-(hydroxyacetyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one 
• 1138150-19-2 5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-(2-(hydroxyacetyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 

Relevant articles and documents

Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit

We synthesized a series of oxazolidinone analogues bearing a N-hydroxyacetyl-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit as homologues of an earlier drug candidate, eperezolid. Several of these compounds exhibited potent in vitro antibacterial activities towards not only Gram-positive, but also Gram-negative and linezolid-resistant pathogens. Compounds 21a and 21b, bearing a thiocarbamate side chain, showed high in vivo activity against methicillin-resistant Staphylococcus aureus SR3637, together with a promising safety profile in terms of weak inhibition of monoamine oxidase and cytochrome P450 isozymes.

NOVEL COMPOUND HAVING HETEROCYCLIC RING

The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A is optionally substituted or fused and represents (A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms; (A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or (A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom; X1 is a single bond, -O-, -S-, -NR2-, -CO-, -CS-, - CONR3-, -NR4CO-, -SO2NR5-, and -NR6SO2- (wherein R2 - R6 are independently hydrogen or lower alkyl), or lower alkylene or lower alkenylene in which one of the preceding groups may intervene; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; R1 is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent, and an antibacterial agent containing the same.