95217-42-8Relevant articles and documents
Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols
Spitz, Cédric,Matteudi, Mélanie,Tintori, Guillaume,Broggi, Julie,Terme, Thierry,Vanelle, Patrice
, p. 15736 - 15742 (2020/12/23)
We report here the intermolecular metal-free addition reaction of functionalized benzyl halides to aldehydes using a super electron donor (SED). The metal-free and mild conditions allowed the formation of 3,4-dihydroisocoumarins and 1,2-diarylethanols with unprecedented functional group tolerance.