952238-93-6

Basic information

• Product Name: PF 477736 (HCl)
• Synonyms: PF 477736 (HCl);(alphaR)-alpha-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide hydrochloride
• CAS NO: 952238-93-6
• Molecular Formula: C22H26ClN7O2
• Molecular Weight: 455.94054
• Mol File: 952238-93-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PF 477736 (HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: PF 477736 (HCl)(952238-93-6)
• EPA Substance Registry System: PF 477736 (HCl)(952238-93-6)

Safety Data

• Hazardous Substances Data: 952238-93-6(Hazardous Substances Data)

Usage

Description

PF 477736 (HCl) is a potent and selective inhibitor of the checkpoint kinase 1 (Chk1), a protein that plays a crucial role in the DNA damage response and cell cycle regulation. It is commonly used in research to study the function of Chk1 and its potential as a therapeutic target in cancer treatment.
Used in Pharmaceutical Industry:
PF 477736 (HCl) is used as a research compound for studying the function of Chk1 and its potential as a therapeutic target in cancer treatment. It has been shown to inhibit the phosphorylation of Chk1 and disrupt the cell cycle, leading to a halt in cell proliferation and ultimately inducing apoptosis in cancer cells.
Used in Cancer Treatment Research:
PF 477736 (HCl) is used as a potential novel cancer treatment. Due to its promising anti-cancer properties, it has been the focus of numerous studies and clinical trials, with the aim of developing new therapeutic strategies for various types of cancer.

Relevant articles and documents

DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS

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