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A facile solvent-free synthesis of 1-alkyl/aralkyl-2-(1-arylsulfonyl alkyl) benzimidazoles using "tBAB" as surface catalyst
Dubey,Prasada Reddy,Srinivas
, p. 1317 - 1322 (2010)
Reaction 2-(α-chloroalkyl)benzimidazoles 1 with aryl sulphinate sodium salt 2 under solvent-free conditions in the presence of tetrabutylammonium bromide as surface catalyst, by simple physical grinding using mortar and pestle, gives 1H-2-(α-arylsulfonylalkyl)benzimidazoles 3. The latter on treatment with alkylating agents under solvent-free conditions results in 1-alkyl/aralkyl-2-(α-arylsulfonylalkyl)benzimidazoles 4. Alternatively, 4 can also be prepared directly from 1-alkyl/aralkyl-2-(α- chloroalkyl)benzimidazoles 5 by reaction with 2, which in turn could be prepared by reaction of 1 with alkylating agents under solvent-free conditions and all these reactions are free from organic solvents including experimental procedures.