952480-19-2 Usage
Description
(3R)-1-methylpiperidine-3-carboxylic acid, also known as N-methylpipecolic acid, is a chemical compound that belongs to the class of piperidine carboxylic acids. It features a three-dimensional molecular structure with a piperidine ring and a carboxylic acid group. This versatile chemical is commonly used in the synthesis of pharmaceuticals and organic compounds due to its unique structural properties. Additionally, it can be found naturally in certain plant species and is known to have potential biological activities, although further research is needed to fully understand its pharmacological properties.
Uses
Used in Pharmaceutical Synthesis:
(3R)-1-methylpiperidine-3-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural properties that facilitate the creation of diverse medicinal compounds.
Used in Organic Compounds Synthesis:
It serves as a building block in the synthesis of organic compounds, contributing to the development of new chemical entities with potential applications in various industries.
Used in Biological Research:
(3R)-1-methylpiperidine-3-carboxylic acid is utilized in biological research to explore its potential biological activities and pharmacological properties, with the aim of discovering new therapeutic agents or gaining insights into biological processes.
Used in Natural Products:
Found in certain plant species, (3R)-1-methylpiperidine-3-carboxylic acid is studied for its natural occurrence and potential benefits, which may lead to the development of novel natural health products or supplements.
Check Digit Verification of cas no
The CAS Registry Mumber 952480-19-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,2,4,8 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 952480-19:
(8*9)+(7*5)+(6*2)+(5*4)+(4*8)+(3*0)+(2*1)+(1*9)=182
182 % 10 = 2
So 952480-19-2 is a valid CAS Registry Number.
952480-19-2Relevant articles and documents
Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants
Zhu, Mei,Zhou, Huiyu,Ma, Ling,Dong, Biao,Zhou, Jinming,Zhang, Guoning,Wang, Minghua,Wang, Juxian,Cen, Shan,Wang, Yucheng
, (2021/06/02)
A novel class of HIV-1 protease inhibitors with flexible piperidine as the P2 ligand was designed with the aim of improving extensive interactions with the active subsites. Many inhibitors exhibited good to excellent inhibitory effect on enzymatic activity and viral infectivity. In particular, inhibitor 3a with (R)-piperidine-3-carboxamide as the P2 ligand and 4-methoxybenzenesulfonamide as the P2’ ligand showed an enzyme Ki value of 29 pM and antiviral IC50 value of 0.13 nM, more than six-fold enhancement of activity compared to DRV. Furthermore, there was no significant change in potency against DRV-resistant mutations and HIV-1NL4?3 variant for 3a. Besides, inhibitor 3a exhibited potent antiviral activity against subtype C variants with low nanomole EC50 values. In addition, the molecular modeling revealed important hydrogen bonds and other favorable van der Waals interactions with the backbone atoms of the protease and provided insight for designing and optimizing more potent HIV-1 protease inhibitors.
SPIROPYRROLIDINES AND THEIR USE AGAINST HCV AND HIV INFECTION
-
Page/Page column 124, (2009/05/30)
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
