952615-13-3

Basic information

• Product Name: N,N-diethyl-N′-(p-tolylcarbamothioyl)benzimidamide
• Synonyms: N,N-diethyl-N′-(p-tolylcarbamothioyl)benzimidamide
• CAS NO: 952615-13-3
• Molecular Weight: 325.478
• Mol File: 952615-13-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-N′-(p-tolylcarbamothioyl)benzimidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-N′-(p-tolylcarbamothioyl)benzimidamide(952615-13-3)
• EPA Substance Registry System: N,N-diethyl-N′-(p-tolylcarbamothioyl)benzimidamide(952615-13-3)

Safety Data

• Hazardous Substances Data: 952615-13-3(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 50458-37-2 N,N-diethylbenzamidine 
• 622-59-3 1-isothiocyanato-4-methylbenzene 

Downstream Products

• 1095593-25-1 C₂₆H₃₀N₄ 
• 952613-79-5 3-(4-chloro-phenyl)-2-(4-phenyl-2-p-tolylamino-thiazol-5-yl)-3H-quinazolin-4-one 
• 1418139-54-4 5-phenyl-N-(4-tolyl)-1,2,4-oxadiazol-3-amine 

Relevant articles and documents

Mercury(II) chloride-mediated desulphurization of amidinothioureas: Synthesis and antimicrobial activity of 3-amino-1,2,4-triazole derivatives

The synthesis of 3-amino-1,2,4-triazole via mercury(II) chloride-mediated cyclization of amidinothiourea is described. This procedure offers a general and efficient route to synthesize the title compound by 3 + 2 annulation reaction. On the basis of the l

Thiazolyl-thiadiazines as Beta Site Amyloid Precursor Protein Cleaving Enzyme-1 (BACE-1) Inhibitors and Anti-inflammatory Agents: Multitarget-Directed Ligands for the Efficient Management of Alzheimer's Disease

Alzheimer's disease (AD) is associated with multiple neuropathological events including β-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibition and neuronal inflammation, ensuing degeneracy, and death to neuronal cells. Targeting such a complex disease via a single target directed treatment was found to be inefficacious. Hence, with an intention to incorporate multiple therapeutic effects within a single molecule, multitarget-directed ligands (MTDLs) have been evolved. Herein, for the first time, we report the discovery of novel thiazolyl-thiadiazines that can serve as MTDLs as evident from the in vitro and in vivo studies. These MTDLs exhibited BACE-1 inhibition down to micromolar range, and results from the in vivo studies demonstrated efficient anti-inflammatory activity with inherent gastrointestinal safety. Moreover, compound 6d unveiled noteworthy antioxidant, antiamyloid, neuroprotective, and antiamnesic properties. Overall, results of the present study manifest the potential outcome of thiazolyl-thiadiazines for AD treatment.

A diversified assembly of 1,2,4-oxadiazol-3-amines: Metallic thiophile catalyzed chemoselective one-pot reaction of aryl isothiocyanates, amidines/guanidines, and hydroxylamine

An efficient one-pot synthesis of 1,2,4-oxadiazol-3-amines from simple starting materials, isothiocyanates, amidines/guanidines, and hydroxylamine, is described. The reaction is facilitated by metallic-thiophile-assisted desulfurization of in situ formed amidino- or guanidinothiourea to give chemoselectively N-hydroxyguanidine intermediates that give exclusively various 1,2,4-oxadiazol-3-amines in good to excellent yields. The reaction mechanistic pathway may proceed through an intramolecular 5-exo-trig cyclization.