95274-63-8

Basic information

• Product Name: 6,7-dimethoxy-2-(trifluoromethyl)-3,1-benzoxazin-4-one
• Synonyms: 4H-3,1-benzoxazin-4-one, 6,7-dimethoxy-2-(trifluoromethyl)-; 6,7-Dimethoxy-2-(trifluoromethyl)-4H-3,1-benzoxazin-4-one
• CAS NO: 95274-63-8
• Molecular Formula: C₁₁H₈F₃NO₄
• Molecular Weight: 275.1807
• Mol File: 95274-63-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 326.779°C at 760 mmHg
• Flash Point: 151.431°C
• Density: 1.475g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 6,7-dimethoxy-2-(trifluoromethyl)-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dimethoxy-2-(trifluoromethyl)-3,1-benzoxazin-4-one(95274-63-8)
• EPA Substance Registry System: 6,7-dimethoxy-2-(trifluoromethyl)-3,1-benzoxazin-4-one(95274-63-8)

Safety Data

• Hazardous Substances Data: 95274-63-8(Hazardous Substances Data)

Upstream product

• 76-05-1 trifluoroacetic acid 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 407-25-0 trifluoroacetic anhydride 
• 20197-92-6 6,7-dimethoxy-1H-benzo[d][1,3]oxazine-2,4-dione 

Relevant articles and documents

Design, Synthesis, and Structure-Activity Relationship of Quinazolinone Derivatives as Potential Fungicides

Plant diseases caused by phytopathogenic fungi reduce the yield and quality of crops. To develop novel antifungal agents, we designed and synthesized eight series of quinazolinone derivatives and evaluated their anti-phytopathogenic fungal activity. The bioassay results revealed that compounds KZL-15, KZL-22, 5b, 6b, 6c, 8e, and 8f exhibited remarkable antifungal activity in vitro. Especially, compound 6c displayed the highest bioactivity against Sclerotinia sclerotiorum, Pellicularia sasakii, Fusarium graminearum, and Fusarium oxysporum, displaying appreciable IC50 values (50% inhibitory concentration) of 2.46, 2.94, 6.03, and 11.9 μg/mL, respectively. A further mechanism interrogation revealed abnormal mycelia, damaged organelles, and changed permeability of cell membranes in S. sclerotiorum treated with compound 6c. In addition, the in vivo bioassay indicated that compound 6c possessed comparable curative and protective effects (87.3 and 90.7%, respectively) to the positive control azoxystrobin (89.5 and 91.2%, respectively) at 100 μg/mL concentration against S. sclerotiorum. This work validated the potential of compound 6c as a new and promising fungicide candidate, contributing to the exploration of potent antifungal agents.