95299-18-6

Basic information

• Product Name: 4-(TrifluoroMethoxy) benzeneacetic acid Methyl ester
• Synonyms: 4-(TrifluoroMethoxy) benzeneacetic acid Methyl ester;Benzeneacetic acid, 4-(trifluoroMethoxy)-, Methyl ester (Related Reference);95299-18-6;Benzeneacetic acid, 4-(trifluoromethoxy)-, methyl ester
• CAS NO: 95299-18-6
• Molecular Formula: C10H9F3O3
• Molecular Weight: 234.1718696
• Mol File: 95299-18-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(TrifluoroMethoxy) benzeneacetic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TrifluoroMethoxy) benzeneacetic acid Methyl ester(95299-18-6)
• EPA Substance Registry System: 4-(TrifluoroMethoxy) benzeneacetic acid Methyl ester(95299-18-6)

Safety Data

• Hazardous Substances Data: 95299-18-6(Hazardous Substances Data)

Upstream product

• 75-63-8 Bromotrifluoromethane 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 67-56-1 methanol 
• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 

Downstream Products

• 852471-18-2 3-benzyloxy-4-(4-trifluoromethoxyphenyl)-1H-pyrazole 
• 1195951-67-7 C₁₀H₇F₃N₂O₂ 
• 1195951-69-9 C₂₆H₂₀F₆N₂O₃ 

Relevant articles and documents

NITROGENATED HETEROCYCLIC COMPOUND

The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF

To provide a novel process for producing a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound or an intermediate thereof useful as an intermediate for production of medicines and agricultural chemicals. A 2-aryl acetate compound represented by the formula (1): wherein R1 is an aryl group or the like, R4 is a C1-3 alkyl group or the like, and X is a leaving group, is reacted with a thioacetic acid compound to form a thioacetyl compound (3), the thioacetyl compound (3) is reacted with a vinyl ketone compound to form a γ-ketosulfide compound (5), which is cyclized under basic conditions to form a dihydrothiophene compound (6), and the dihydrothiophene compound (6) is oxidized by using an oxidizing agent to produce a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound (7).

Novel benzimidazole derivatives as selective CB2 agonists

The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.