953803-77-5

Basic information

• Product Name: diethyl {[(4-bromo-3-methoxyphenyl)amino]methylene}malonate
• Synonyms: diethyl {[(4-bromo-3-methoxyphenyl)amino]methylene}malonate
• CAS NO: 953803-77-5
• Molecular Weight: 372.216
• Mol File: 953803-77-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl {[(4-bromo-3-methoxyphenyl)amino]methylene}malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl {[(4-bromo-3-methoxyphenyl)amino]methylene}malonate(953803-77-5)
• EPA Substance Registry System: diethyl {[(4-bromo-3-methoxyphenyl)amino]methylene}malonate(953803-77-5)

Safety Data

• Hazardous Substances Data: 953803-77-5(Hazardous Substances Data)

Upstream product

• 19056-40-7 4-bromo-3-methoxyaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1361235-53-1 ethyl 6-bromo-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 953801-10-0 ethyl 4-[(2,3-dichlorophenyl)amino]-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate 
• 953802-66-9 ethyl 6-bromo-4-[(2,3-dichlorophenyl)amino]-7-methoxyquinoline-3-carboxylate 
• 476194-45-3 ethyl 6-bromo-4-chloro-7-methoxyquinoline-3-carboxylate 

Relevant articles and documents

3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile

The optimization of compounds from the 3-amido-4-anilinoquinolines series of CSF-1R kinase inhibitors is described. The series has excellent activity and kinase selectivity. Excellent physical properties and rodent PK profiles were achieved through the introduction of cyclic amines at the quinoline 6-position. Compounds with good activity in a mouse PD model measuring inhibition of pCSF-1R were identified.

4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS

The invention relates to chemical compounds of formula IA or IB: formula IA IB or pharmaceutically acceptable salts thereof which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of tr