954109-21-8

Basic information

• Product Name: (S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-trimethylsilyloxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one
• Synonyms: (S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-trimethylsilyloxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one
• CAS NO: 954109-21-8
• Molecular Weight: 686.828
• Mol File: 954109-21-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-trimethylsilyloxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-trimethylsilyloxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one(954109-21-8)
• EPA Substance Registry System: (S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-trimethylsilyloxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one(954109-21-8)

Safety Data

• Hazardous Substances Data: 954109-21-8(Hazardous Substances Data)

Upstream product

• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 954109-25-2 (S)-3-{(R)-2-[(S)-(4-fluorophenylamino)-(4-hydroxyphenyl)methyl]-4-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]butyryl}-4-phenyloxazolidin-2-one 
• 942485-56-5 (S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one 
• 1158954-83-6 C₁₆H₁₈FNOSi 

Downstream Products

• 954109-24-1 (3R,4S)-1-(4-fluorophenyl)-3-{2-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]ethyl}-4-(4-trimethylsilyloxy phenyl)-azetidin-2-one 
• 954109-23-0 (3R,4S)-4-[4-hydroxy-phenyl]-1-(4-fluorophenyl)-3-{2-(2-(4-fluorophenyl)-[1,3]dioxolan-2-yl)-ethyl}-azetidine-2-one 

Relevant articles and documents

PROCESSES FOR PREPARING INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF EZETIMIBE

The invention relates, in general, to an improved process for the preparation of the compounds (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one and (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one, which are key intermediates for the synthesis of ezetimibe, as well as the use of these intermediates for the preparation of ezetimibe.