954114-87-5Relevant articles and documents
Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations
Kasper, Amanda C.,Moon, Eui Jung,Hu, Xiangqian,Park, Yongho,Wooten, Ceshea M.,Kim, Hyoungsu,Yang, Weitao,Dewhirst, Mark W.,Hong, Jiyong
scheme or table, p. 3783 - 3786 (2010/03/01)
We have shown that manassantin A downregulated the HIF-1α expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin