954143-62-5

Basic information

• Product Name: (2,6-dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)methyl 2,2,2-trifluoroacetate
• Synonyms: (2,6-dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)methyl 2,2,2-trifluoroacetate
• CAS NO: 954143-62-5
• Molecular Weight: 448.053
• Mol File: 954143-62-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2,6-dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)methyl 2,2,2-trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2,6-dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)methyl 2,2,2-trifluoroacetate(954143-62-5)
• EPA Substance Registry System: (2,6-dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)methyl 2,2,2-trifluoroacetate(954143-62-5)

Safety Data

• Hazardous Substances Data: 954143-62-5(Hazardous Substances Data)

Upstream product

• 1117976-38-1 ((S)-(2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methyl) N-succinimidyl carbonate 
• 103343-47-1 3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one 
• 1205122-21-9 C₄₃H₄₆Cl₄N₂O₁₂S 
• 76-05-1 trifluoroacetic acid 
• 1205122-19-5 C₂₃H₂₆Cl₄O₇ 
• 1205122-14-0 C₂₀H₂₀Cl₄O₄ 
• 1205122-10-6 C₂₉H₂₆Cl₄O₃ 
• 1205122-09-3 C₂₄H₂₀Cl₄O₂ 
• 1205122-08-2 C₃₀H₃₂Cl₄O₇ 
• 1205122-07-1 C₃₃H₃₂Cl₄O₁₀ 
• 1205122-06-0 C₄₅H₄₀Cl₄O₁₃ 
• 1205122-05-9 C₃₆H₃₄Cl₄N₂O₈ 
• 1205122-04-8 C₄₄H₄₈Cl₄N₂O₈Si 
• 1205122-02-6 C₂₃H₂₅Cl₄NO₆ 

Downstream Products

• 934562-65-9 (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methyl alcohol 
• 954143-60-3 (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methyl (2R)-2-(tert-butoxycarbonylamino)propanoate 
• 934562-89-7 C₂₁H₁₃Cl₅O₃ 
• 954143-59-0 (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methyl nonanoate 

Relevant articles and documents

IMPROVED SYNTHESIS OF CAPURAMYCIN AND ITS ANALOGUES

Provided herein are compounds of Formula I, Formula II, and Formula X, which are useful for the treatment of infectious diseases. Also provided herein are processes for preparing 1-[5-0-[4,6-Dideoxy-6-oxo-6-[[[(3S)-hexahydro-2-oxo-1H-azepine]-3-y1]amino]-Pβ-L-erythro-4- hexenopyranosyl]-3-0-methyl 6-deoxy-6-amino-α-L-talofuranuronosyl]-1,2,3,4-tetrahydro-2,4- dioxopyrimidine (capuramycin), analogues thereof, and intermediates useful therefore. Also provided herein are III, IIIa, and IX, which are useful in the process for preparing capuramycin and/or a certain compound of Formula I.

(2,6-Dichloro-4-alkoxyphenyl)-(2,4-dichlorophenyl)methyl trichloroacetimidates: Protection of alcohols and carboxylic acids in solution or on polymer support

(2,6-Dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)-methyl trichloroacetimidate can be efficiently activated by TMSOTf (10-100 mol%) to react with alcohols and carboxylic acids. Under these conditions a wide variety of alcohols can be transformed into the corresponding ethers in excellent yields with a slight excess of the trichloroacetimidate. The resulting ethers are not susceptible to typical deprotection conditions for benzyl and 4-methoxybenzyl ether groups, however, they can be conveniently deprotected by treatment with 30-50% trifluoroacetic acid in dichloromethane. Polymer-bound (2,6-dichloro-4-alkoxyphenyl)-(2,4-dichlorophenyl)methyl trichloroacetimidate is useful for immobilization of alcohols and carboxylic acids.

Acid- and base-stable esters: A new protecting group for carboxylic acids

An acid- and base-stable protecting group for carboxylic acids is described. The esters of (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl) methanol are stable to Bransted and Lewis acids, Bronsted bases, and a wide variety of nucleophiles; however, the esters can be conveniently deprotected by a solvolytic displacement reaction with 20% trifluoroacetic acid. Georg Thieme Verlag Stuttgart.