95417-66-6

Basic information

• Product Name: 1'-benzylspiro<(1,4-dihydronaphthalene)-1,4'-piperidine>
• Synonyms: 1'-benzylspiro<(1,4-dihydronaphthalene)-1,4'-piperidine>
• CAS NO: 95417-66-6
• Molecular Weight: 289.42
• Mol File: 95417-66-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1'-benzylspiro<(1,4-dihydronaphthalene)-1,4'-piperidine>(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-benzylspiro<(1,4-dihydronaphthalene)-1,4'-piperidine>(95417-66-6)
• EPA Substance Registry System: 1'-benzylspiro<(1,4-dihydronaphthalene)-1,4'-piperidine>(95417-66-6)

Safety Data

• Hazardous Substances Data: 95417-66-6(Hazardous Substances Data)

Upstream product

• 95449-63-1 9b-(N-benzylcarbamoylmethyl)-1,2,3a,4,5,9b-hexahydronaphtho<2,1-b>furan-2-one 
• 95449-62-0 1,2,3a,4,5,9b-hexahydro-9b-(methoxycarbonylmethyl)naphtho<2,1-b>furan-2-one 
• 95417-64-4 1,1-bis(methoxycarbonylmethyl)-2-tetralone 
• 95417-65-5 1-benzylspiro-2'-ol 

Downstream Products

• 95417-67-7 L 687384 

Relevant articles and documents

Synthesis and structure-activity relationship of spiro[isochroman-piperidine] analogs for inhibition of histamine release. IV

Various 1'-(o, m, and/or p-substituted benzyl) (5), 1'-(heterocyclic arylmethyl) (6), and 1'-acyl (7) analogs of spiro[isochroman-3,4'-piperidin]-1-one were prepared and tested for inhibitory activity on the compound 48/80-induced release of histamine from mast cells. The biological results suggested that the activity is mainly affected by the lipophilicity rather than by the electrostatic character of the 1'-substituent. 4-Benzylspiro[cyclohexane-1,3'-hexahydroisochroman]-1'-one (17) and 9-benzyl-1-oxa-spiro[5.5]undecan-2-one (18) were prepared and found to be inactive, implying that the benzene moiety in the isochroman ring is essential for the activity.