956598-29-1Relevant articles and documents
Synthesis and studies of new 6-[halo(diphenyl)methyl]- and 6-(thiophen-2-ylmethyl)pyrimidin-4(3H)-ones as possible HIV-1 reverse transcriptase inhibitors
Valuev-Elliston,Ivanov,Orlinson,Gerasimov,Brunilina,Zakharova,Kochetkov,Novakov,Navrotskii
, p. 797 - 801 (2014/01/23)
Six new 6-[halo(diphenyl)methyl]- and 6-(thiophen-2-ylmethyl)pyrimidin- 4(3H)-one derivatives were synthesized and studied for biological activity. The studies showed that the 6-(thiophen-2-ylmethyl)pyrimidin-4(3H)-one derivatives inhibited activity of the HIV-1 recombinant reverse transcriptase in the micromolar range of concentrations. The 6-[halo-(diphenyl)methyl]pyrimidin-4(3H) -one derivative showed no activity in the concentrations up to 200 μmol mL-1.