956721-96-3 Usage
General Description
4-(Isoxazol-4-yl)-2-(methylthio)pyrimidine is a chemical compound that consists of a pyrimidine ring containing an isoxazole ring at position 4 and a methylthio group at position 2. It has potential applications in the pharmaceutical industry due to its structural features, which may contribute to its biological activity. The isoxazole ring is a five-membered heterocyclic ring containing nitrogen and oxygen atoms, while the methylthio group is a sulfur-containing moiety. These structural elements may impart specific chemical and biological properties to the compound, making it valuable for further study and potential drug development. However,
Check Digit Verification of cas no
The CAS Registry Mumber 956721-96-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,6,7,2 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 956721-96:
(8*9)+(7*5)+(6*6)+(5*7)+(4*2)+(3*1)+(2*9)+(1*6)=213
213 % 10 = 3
So 956721-96-3 is a valid CAS Registry Number.
956721-96-3Relevant articles and documents
MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
-
Paragraph 0435; 0438, (2017/01/31)
The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the MDM2 E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
