957147-18-1

Basic information

• Product Name: 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• Synonyms: 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
• CAS NO: 957147-18-1
• Molecular Weight: 415.458
• Mol File: 957147-18-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide(957147-18-1)
• EPA Substance Registry System: 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide(957147-18-1)

Safety Data

• Hazardous Substances Data: 957147-18-1(Hazardous Substances Data)

Usage

General Description

3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide, also known as AMG 738, is a novel chemical compound with potential pharmaceutical applications. It contains a benzamide backbone with an ethynyl and methyl group, as well as a trifluoromethyl and piperazinylmethyl substituent. 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide has been identified as a potential inhibitor of the fibroblast growth factor receptor (FGFR) and is being studied for its potential in cancer therapy. FGFR inhibitors have shown promise in the treatment of various cancers, including lung and breast cancer, and compounds like AMG 738 are being investigated for their therapeutic potential in targeting this pathway. Further research is needed to fully understand the pharmacological properties and potential uses of this chemical compound.

Upstream product

• 320-37-6 4-nitro-2-(trifluoromethyl)benzoic acid 
• 859027-06-8 (4-nitro-2-(trifluoromethyl)phenyl)methanol 
• 694499-22-4 1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene 
• 89976-12-5 1-methyl-4-nitro-2-(trifluoromethyl) benzene 
• 109-01-3 1-methyl-piperazine 
• 50551-17-2 4-nitro-2-(trifluoromethyl)benzaldehyde 
• 943320-50-1 3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl) phenyl)benzamide 
• 1066-54-2 trimethylsilylacetylene 
• 694499-26-8 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 
• 1001203-03-7 3-ethynyl-4-methylbenzoic acid 
• 82998-57-0 3-iodo-4-toluic acid 
• 1416241-81-0 3-ethynyl-4-methylbenzoyl chloride 
• 52107-98-9 3-iodo-4-methylbenzoyl chloride 
• 1255099-13-8 methyl 3-ethynyl-4-methylbenzoate 

Downstream Products

• 1421685-09-7 C₃₀H₂₉F₃N₆O₂ 
• 1421685-06-4 C₃₀H₂₉F₃N₆O 
• 1448705-58-5 C₃₆H₄₃F₃N₆O₂Si 
• 1421684-97-0 C₃₀H₂₈F₃N₅O 
• 1421684-98-1 C₃₀H₂₉F₃N₆O 
• 1421684-99-2 3-([1,2,4]triazolo[1,5-a]pyrimidin-6-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)-phenyl)benzamide 
• 1421685-07-5 C₃₂H₃₁F₃N₆O 
• 1431221-13-4 C₃₈H₄₅F₃N₆O₂Si 
• 1421685-08-6 C₃₅H₃₁F₃N₆O 
• 943319-70-8 ponatinib 

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