957753-07-0

Basic information

• Product Name: (R)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-phenylpropanoate
• Synonyms: (R)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-phenylpropanoate
• CAS NO: 957753-07-0
• Molecular Weight: 378.469
• Mol File: 957753-07-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (R)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-phenylpropanoate(957753-07-0)
• EPA Substance Registry System: (R)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-phenylpropanoate(957753-07-0)

Safety Data

• Hazardous Substances Data: 957753-07-0(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 51803-69-1 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)acetate 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 1446274-25-4 (S)-Se-((9H-fluorenyl)methyl) 2-((tert-butoxycarbonyl)amino)-3-methylbutaneselenoate 
• 21685-51-8 D-phenylalanine methyl ester 
• 187884-05-5 (2S)-2-[(tert-butoxycarbonyl)amino]-3-methylbutanethioic S-acid 
• 13734-41-3 t-Boc-L-valine 
• 906748-11-6 2-(2,4-dinitro-benzensulfonamido)-3-phenylpropionic acid methyl ester 

Downstream Products

• 145313-30-0 (R)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester 
• 14474-71-6 2,5-piperazinedione, 3-benzyl-6-isopropyl- 
• 88224-13-9 N-tert-Butyloxycarbonyl-L-valyl-L-phenylalanin-allylester 

Relevant articles and documents

A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H

N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.

A traceless approach to amide and peptide construction from thioacids and dithiocarbamate-terminal amines

A novel and traceless strategy has been devised that allows a coupling of thioacids and dithiocarbamate-terminal amines. This strategy had been assumed to be dependent on the attachment of a functional equivalent of a cysteine side chain in earlier native chemical ligation approaches. This approach enables the traceless removal of CS2 to directly generate the desired amide bond and is compatible with a range of unprotected side chains of amino acid. The ability to produce amide or peptides by a traceless removal of the auxiliary is a significant virtue of the method. Meanwhile, the application of this new peptide-bond-forming reaction to the synthesis of novel endomorphin (EM) derivatives with various binding potencies was realized.

Epimerization-free block synthesis of peptides from thioacids and amines with the sanger and mukaiyama reagents

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