95847-63-5

Basic information

• Product Name: Benzamide, 2-amino-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
• CAS NO: 95847-63-5
• Molecular Formula: C19H26N6O
• Molecular Weight: 354.455
• Mol File: 95847-63-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-amino-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-(95847-63-5)
• EPA Substance Registry System: Benzamide, 2-amino-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-(95847-63-5)

Safety Data

• Hazardous Substances Data: 95847-63-5(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 33386-20-8 1-(pyrimidin-2-yl)-4-(4-aminobutyl)piperazine 
• 33386-14-0 4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyronitrile 
• 20980-22-7 N-(2-pyridinyl)piperazine 

Relevant articles and documents

Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-b icyclo[2.2.1]heptanedicarboxime (Tandospirone) and related compounds

A series of cyclic imides bearing a ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT(1A) receptor sites. Structure-activity relationships within these series are discussed. One of these compounds, (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (1: tandospirone), was found to be equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. Tandospirone (1) is currently undergoing clinical evaluation as a selective anxiolytic agent.