95881-83-7

Basic information

• Product Name: 3-Chloro-5-methoxypyridine
• Synonyms: 3-CHLORO-5-METHOXYPYRIDINE;3-Chloro-5-methoxypyriidine
• CAS NO: 95881-83-7
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• Product Categories: Heterocyclic Series;pharmacetical;Pyridines
• Mol File: 95881-83-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 198.363 °C at 760 mmHg
• Flash Point: 73.767 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 0.509mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-Chloro-5-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-methoxypyridine(95881-83-7)
• EPA Substance Registry System: 3-Chloro-5-methoxypyridine(95881-83-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 95881-83-7(Hazardous Substances Data)

Usage

General Description

3-Chloro-5-methoxypyridine is a chemical compound that is most likely worked with in controlled laboratory settings. As the name suggests, it is a derivative of the pyridine molecule which has been modified by adding a chloro group at the third position and a methoxy group at the fifth. This designates it as an organic halide and ether. It doesn't occur naturally and has to be synthesized in the lab for use in chemical reactions or as an intermediate in the production of more complex molecules. Specific safety or hazard information about this chemical is not readily accessible, which suggests it's not commonly used or involved in everyday applications.

InChI:InChI=1/C6H6ClNO/c1-9-6-2-5(7)3-8-4-6/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 2457-47-8 3,5-dichloropyridine 
• 186581-53-3 diazomethane 
• 74115-12-1 5-chloropyridin-3-ol 
• 124-41-4 sodium methylate 

Downstream Products

• 214976-36-0 3-chloro-5-methoxyisonicotinic acid 
• 64436-92-6 3-amino-5-methoxypyridine 
• 214976-38-2 3-(5-Chloro-2-fluoro-benzyl)-5-methoxy-isonicotinic acid methyl ester 
• 214976-39-3 3-(5-Chloro-2-fluoro-benzyl)-5-methoxy-isonicotinic acid 

Relevant articles and documents

Creating an antibacterial with in vivo efficacy: Synthesis and characterization of potent inhibitors of the bacterial cell division protein FTSZ with improved pharmaceutical properties

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.

The reaction of 5-chloro derivatives of 3-pyridinol and 3- methoxypyridine with various amines under aryne-forming conditions

The reactions of 5-chloro-3-pyridinol (1) and 5-chloro-3-methoxy- pyridine (6) with various lithium amides (2') in THF or free amine solvent (2) have been studied and the results reported herein. In most cases, 5- aminated products were exclusively formed

NEW REACTIONS OF PYRIDINES AND TOTAL SYNTHESIS OF THE FUNGAL TOXIN ORELLANINE

Dihalogenated pyridines react easily with sulphur nucleophiles, in dipolar aprotic solvents (DMF), to afford the products of mono- or of bis-substitution depending on the experimental conditions.On the contrary, with oxygen nucleophiles the bis-substituted products can be obtained only with some particular substrates.A new and efficient procedure to effect the homo-coupling of halogenoarenes will be presented.This reaction, wich occurs under the influence of low-valent nickel complexes, allowed us to effect the total synthesis of Orellanine, the lethal toxin of Cortinarius orellanus mushroom, as well as the syntheses of its decompositionproducts Orellinine and Orelline.The chemical properties of these three products and their behaviour towards UV irradiation will be presented and discussed.