958863-36-0

Basic information

• Product Name: 2-(diethoxyMethyl)-5,6-difluoro-1H-benzo[d]iMidazole
• Synonyms: 2-(diethoxyMethyl)-5,6-difluoro-1H-benzo[d]iMidazole;2-(Diethoxymethyl)-5,6-difluoro-1H-benzimidazole
• CAS NO: 958863-36-0
• Molecular Formula: C₁₂H₁₄F₂N₂O₂
• Molecular Weight: 256
• EINECS: -0
• Mol File: 958863-36-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.285
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(diethoxyMethyl)-5,6-difluoro-1H-benzo[d]iMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethoxyMethyl)-5,6-difluoro-1H-benzo[d]iMidazole(958863-36-0)
• EPA Substance Registry System: 2-(diethoxyMethyl)-5,6-difluoro-1H-benzo[d]iMidazole(958863-36-0)

Safety Data

• Hazardous Substances Data: 958863-36-0(Hazardous Substances Data)

Usage

General Description

2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole, also known as benzo[d]imidazole-5,6-difluoro-1H,2-diol diethyl acetal, is a chemical compound with the molecular formula C15H18F2N2O2. It is a purine analog that has potential use in pharmaceutical and research applications. Its molecular structure consists of a benzo[d]imidazole ring with two fluorine atoms at positions 5 and 6, as well as a diethoxymethyl group attached at the 2-position. 2-(diethoxymethyl)-5,6-difluoro-1H-benzo[d]imidazole has potential as an antiviral agent, and it may also have applications in the synthesis of other pharmaceutical compounds due to its unique structural features. Further research into its properties and potential uses may reveal additional applications for this compound in the future.

Upstream product

• 78056-39-0 4,5-difluoro-2-nitroaniline 
• 76742-48-8 2,2-diethoxy-ethanimidic acid methyl ester 
• 6136-93-2 2,2-diethoxyacetonitrile 
• 76179-40-3 2-amino-4,5-difluoroaniline 
• 6065-82-3 Ethyl diethoxyacetate 
• 1331832-22-4 2,2-diethoxy-N-methylacetamide 

Downstream Products

• 958863-37-1 2-(diethoxymethyl)-5,6-difluoro-1-methyl-1H-benzimidazole 
• 118469-25-3 5,6-difluoro-1-methyl-1H-benzimidazole-2-carbaldehyde 

Relevant articles and documents

Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi

Crop diseases caused by fungi threaten food security and exacerbate the food crisis. Inspired by the application of fungicide candidates from natural products in agrochemical discovery, a series of luotonin A derivatives were designed, synthesized, and evaluated for their antifungal activities against five plant fungi. Most of these compounds exhibited significant fungicidal activity against Botrytis cinerea in vitro with EC50 values less than 1 μg/mL. Among them, compounds w7, w8, w12, and w15 showed superior antifungal activity against B. cinerea with EC50 values of 0.036, 0.050, 0.042, and 0.048 μg/mL, respectively, which were more potent than boscalid (EC50 = 1.790 μg/mL). Preliminary mechanism studies revealed that compound w7 might pursue its antifungal activity by disrupting the fungal cell membrane and cell wall. Moreover, in vivo bioassay also indicated that compound w7 could be effective for the control of B. cinerea. The above results evidenced the potential of luotonin A derivatives as novel and promising candidate fungicides.

BENZIMIDAZOLYL COMPOUNDS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein Y1, R17, R2, R4, R5, R6, R7, R8, X2 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.