958972-79-7

Basic information

• Product Name: C₂₁H₁₈N₄O₂S₂
• CAS NO: 958972-79-7
• Molecular Weight: 422.532
• Mol File: 958972-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₈N₄O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₈N₄O₂S₂(958972-79-7)
• EPA Substance Registry System: C₂₁H₁₈N₄O₂S₂(958972-79-7)

Safety Data

• Hazardous Substances Data: 958972-79-7(Hazardous Substances Data)

Upstream product

• 32558-16-0 N-[5-(2-bromoacetyl)-4-methylthiazol-2-yl]benzamide 
• 37014-08-7 3-methoxyphenylthiourea 

Relevant articles and documents

4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing

The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library are reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy were assayed using epithelial cells expressing human ΔF508-CFTR. These structure-activity data establish that the bithiazole substructure plays a critical function; eight novel methylbithiazole correctors were identified with low micromolar potencies.