959237-64-0

Basic information

• Product Name: 2,4-DICHLORO-8-FLUORO-QUINAZOLINE
• Synonyms: 2,4-DICHLORO-8-FLUORO-QUINAZOLINE;4-dichloro-8-fluoroquinazoline;2,4- two-8- chlorinefluorinequinazoline
• CAS NO: 959237-64-0
• Molecular Formula: C₈H₃Cl₂FN₂
• Molecular Weight: 217.03
• Mol File: 959237-64-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 277.3 °C at 760 mmHg
• Flash Point: 121.5 °C
• Appearance: /
• Density: 1.571 g/cm³
• Vapor Pressure: 0.00772mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-DICHLORO-8-FLUORO-QUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-8-FLUORO-QUINAZOLINE(959237-64-0)
• EPA Substance Registry System: 2,4-DICHLORO-8-FLUORO-QUINAZOLINE(959237-64-0)

Safety Data

• Hazardous Substances Data: 959237-64-0(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-8-fluoro-quinazoline is a chemical compound that belongs to the quinazoline family. It is characterized by the presence of two chlorine atoms and one fluorine atom on a quinazoline ring structure. 2,4-DICHLORO-8-FLUORO-QUINAZOLINE is often used as a building block in the synthesis of pharmaceuticals and agrochemicals, due to its potential to act as an intermediate in the production of these substances. Its unique structure and reactivity make it a valuable precursor in the development of various compounds with biological and industrial applications. Additionally, 2,4-Dichloro-8-fluoro-quinazoline may have potential uses in research and development of new materials and chemical processes.

InChI:InChI=1/C8H3Cl2FN2/c9-7-4-2-1-3-5(11)6(4)12-8(10)13-7/h1-3H

Upstream product

• 590-28-3 potassium cyanate 
• 825-22-9 3-fluoroanthranilic acid 
• 959236-96-5 8-fluoroquinazoline-2,4(1H,3H)-dione 

Downstream Products

• 1292802-72-2 2-N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-8-fluoro-4-N-(furan-2-ylmethyl)quinazoline-2,4-diamine 
• 139996-64-8 2-chloro-8-fluoro-N-methyl-N-phenylquinazolin-4-amine 

Relevant articles and documents

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.

Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines

Quinazolines bearing a secondary 4-(arylamino) substituent demonstrate an SAR for inhibition of the gastric (H+/K+)-ATPase different from the previously described 3-acylquinolines, suggesting that, although these compounds are also K+-competitive, they probably bind to the enzyme in a different orientation.Compounds bearing a tertiary 4-(arylamino)substituent, however, in particular 4-(N-methylarylamino), appear to possess an SAR quite similar to the 3-acylquinolines.We show that this arises from the effect of the N-methylation, which is to orientate the 4-(arylamino) substituent syn to C5, analogous to the 3-acylquinolines.Compounds possessing both a 4-(N-methylarylamino) substituent and a 2-(arylamino) substituent proved to be very potent, K+-competitive inhibitors of K+-stimulated ATPase activity with Ki values down to 12 nM.Some compounds also proved to be effective inhibitors of stimulated acid secretion in both the rat and dog when dosed intravenously.However, although a number of these demonstrated activity after oral administration in the dog, the level and variability precluded further evaluation.