959414-77-8Relevant articles and documents
Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α
Tsumura, Kana,Suzuki, Akane,Tsuzuki, Takeo,Tanimoto, Shuho,Kaneko, Hajime,Matsumura, Shuichi,Imoto, Masaya,Umezawa, Kazuo,Takahashi, Daisuke,Toshima, Kazunobu
experimental part, p. 6357 - 6366 (2011/10/10)
2-Phenylquinoline (1) degraded proteins under photo-irradiation with long-wavelength UV light without additives and under neutral conditions. We designed and synthesized a 2-phenylquinoline-estrogen receptor-α (ER-α) agonist (hybrid 2) and a 2-phenylquino