959633-82-0Relevant articles and documents
Synthesis of (+)-vinblastine and its analogues
Miyazaki, Tohru,Yokoshima, Satoshi,Simizu, Siro,Osada, Hiroyuki,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 4737 - 4740 (2007)
(Chemical Equation Presented) A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.