959923-25-2Relevant articles and documents
Synthesis of natural products from the Indian neem tree Azadirachta indica
Veitch, Gemma E.,Pinto, Andrea,Boyer, Alistair,Beckmann, Edith,Anderson, James C.,Ley, Steven V.
, p. 569 - 572 (2008)
The synthesis of five natural products (3, 6, 7, 10, and 14), isolated from the Indian neem tree Azadirachta indica, is reported from a common intermediate (2). The judicious choice of transacetalization conditions allows efficient access to both the azadirachtinin (9 and 10) and the azadirachtin (3, 6, 7, and 14) skeletons
A relay route for the synthesis of azadirachtin
Veitch, Gemma E.,Beckmann, Edith,Burke, Brenda J.,Boyer, Alistair,Ayats, Carles,Ley, Steven V.
, p. 7633 - 7635 (2008/09/19)
(Chemical Equation Presented) 22 Years in the making: Azadirachtin (1) was synthesized for the first time by a highly convergent approach, utilizing a Claisen rearrangement and a radical cyclization as key steps. End-game strategies relied on intermediate 2, which could be obtained by synthetic methods as well as by degradation of 1. Bn = benzyl, TBS = tert- butyldimethylsilyl.
