960055-68-9 Usage
Description
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate, also known as Panobinostat lactate, is a histone deacetylase (HDAC) inhibitor. It was approved by the FDA for the treatment of multiple myeloma and is currently being investigated for a number of hematological cancers as well as other indications.
Uses
Used in Oncology:
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate is used as an HDAC inhibitor for the treatment of multiple myeloma. It has been approved by the FDA, Japan, and the EU in combination with bortezomib and dexamethasone for the treatment of adults with relapsed and/or refractory multiple myeloma.
Used in Pharmaceutical Industry:
N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate is used as a drug candidate for the development of new therapies for hematological cancers and other indications. It was discovered and developed by Novartis, a pharmaceutical company.
Synthesis
Grandberg synthesis of 2-methyltryptamine (223) was
accomplished in 47% yield by heating phenylhydrazine (221)
with 5-chloro-2-pentanone (222). Reductive amination of
223 with (E)-3-(4-formyl-phenyl)-acrylic acid methyl ester
(224) and sodium borohydride followed by formation of the
hydrochloride salt provided amine hydrochloride 225 in high
purity. Saponification of the methyl ester followed by reaction
with hydroxylamine provided panobinostat in high overall yield.
The free base was treated with racemic lactic acid and
recrystallized in water to give panobinostat lactate (XXVIII).
Check Digit Verification of cas no
The CAS Registry Mumber 960055-68-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,6,0,0,5 and 5 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 960055-68:
(8*9)+(7*6)+(6*0)+(5*0)+(4*5)+(3*5)+(2*6)+(1*8)=169
169 % 10 = 9
So 960055-68-9 is a valid CAS Registry Number.
960055-68-9Relevant articles and documents
SALTS OF N-HYDROXY-3-[4-[[[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]AMINO]METHYL]PHENYL]-2E-2-PROPENAMIDE
-
Page/Page column 36; 37, (2008/06/13)
Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide are prepared and characterized.
