960064-03-3

Basic information

• Product Name: C₁₃H₈ClN₃O₄
• Synonyms: C₁₃H₈ClN₃O₄
• CAS NO: 960064-03-3
• Molecular Weight: 305.677
• Mol File: 960064-03-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₈ClN₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₈ClN₃O₄(960064-03-3)
• EPA Substance Registry System: C₁₃H₈ClN₃O₄(960064-03-3)

Safety Data

• Hazardous Substances Data: 960064-03-3(Hazardous Substances Data)

Upstream product

• 3261-05-0 5-chlorobenzofuran-3(2H)-one 
• 4750-57-6 1-methyl-5-nitro-1H-imidazole-2-carbaldehyde 

Relevant articles and documents

Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2 H)-benzofuranone derivatives

A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2 H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2 H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities.