960119-51-1

Basic information

• Product Name: C₁₃H₁₈NI
• Synonyms: C₁₃H₁₈NI
• CAS NO: 960119-51-1
• Molecular Weight: 315.197
• Mol File: 960119-51-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₈NI(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₈NI(960119-51-1)
• EPA Substance Registry System: C₁₃H₁₈NI(960119-51-1)

Safety Data

• Hazardous Substances Data: 960119-51-1(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant articles and documents

Cycloisomerization of Carbamoyl Chlorides in Hexafluoroisopropanol: Stereoselective Synthesis of Chlorinated Methylene Oxindoles and Quinolinones

Hexafluoroisopropanol (HFIP) was employed as an additive for the generation of 3-(chloromethylene)oxindoles via the chloroacylation of alkyne-tethered carbamoyl chlorides. This reaction avoids the use of a metal catalyst and accesses products in high yields and stereoselectivities. Additionally, this reaction is scalable and proved amenable to a series of product derivatizations, including the synthesis of nintedanib. The reactivity of alkene-tethered carbamoyl chlorides with hexafluoroisopropanol (HFIP) was harnessed towards the synthesis of 2-quinolinones.