96047-32-4

Basic information

• Product Name: 3-FLUORO-4-METHOXYBENZYL ALCOHOL
• Synonyms: (3-FLUORO-4-METHOXYPHENYL)METHANOL;3-FLUORO-4-METHOXYBENZYL ALCOHOL;RARECHEM AL BD 0055;3-Fluoro-4-methoxybenzylalcohol98%;2-Fluoro-4-(hydroxymethyl)anisole
• CAS NO: 96047-32-4
• Molecular Formula: C₈H₉FO₂
• Molecular Weight: 156.15
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 96047-32-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 251.4°Cat760mmHg
• Flash Point: 122.7°C
• Appearance: /
• Density: 1.187g/cm³
• Vapor Pressure: 0.0108mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 3-FLUORO-4-METHOXYBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-METHOXYBENZYL ALCOHOL(96047-32-4)
• EPA Substance Registry System: 3-FLUORO-4-METHOXYBENZYL ALCOHOL(96047-32-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 96047-32-4(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-methoxybenzyl alcohol is a chemical compound with the molecular formula C8H9FO2. It is a benzyl alcohol derivative with a fluorine atom located at the 3-position and a methoxy group at the 4-position of the benzene ring. 3-FLUORO-4-METHOXYBENZYL ALCOHOL is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the preparation of various organic compounds. 3-Fluoro-4-methoxybenzyl alcohol may have potential applications in the field of medicinal chemistry and organic synthesis.

InChI:InChI=1/C8H9FO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-4,10H,5H2,1H3

Upstream product

• 369-30-2 methyl 3-fluoro-4-methoxybenzoate 
• 351-54-2 3-fluoro-p-anisaldehyde 

Downstream Products

• 403-20-3 3-fluoro-p-anisic acid 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 1428882-96-5 C₉H₁₂FO₄P 
• 1428882-86-3 C₁₀H₁₄FO₄P 
• 331-61-3 3-fluoro-4-methoxybenzyl bromide 
• 331-62-4 3-fluoro-4-methoxybenzonitrile 
• 1224724-31-5 (5-biphenyl-4-yl-6-chloro-1H-benzoimidazol-2-ylsulfanylmethyl)phosphonic acid mono-(3-fluoro-4-methoxybenzyl) ester 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 

Relevant articles and documents

Design, synthesis, and in vitro/vivo anticancer activity of 4-substituted 7-(3-fluoro-4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidines

In this paper, we report the design and synthesis of 4-substituted 7-(3-fluoro-4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidines of scaffold 6 as anticancer agents. A total of 19 derivatives of scaffold 6 bearing a C-4 alkoxy, dialkylamino, alkyl, vinyl, or phenyl substituent were synthesized and evaluated. Among them, compound 6q having a C-4 ethyl group and a benzylic methyl group showed the most potent in vitro anticancer activity, inhibiting the proliferation of Hela, MDA-MB-231, and MDA-MB-426 cancer cells at submicromolar concentrations (GI50: 0.11–0.58 μM). Compound 6q arrested the cell cycle of MDA-MB-231 at G2/M phase, and showed in vivo activity on nude mice bearing MDA-MB-231 xenografts. Compound 6q has served as an anticancer lead for further optimization.

Anti-tubercular agents. Part 8: Synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles

A series of 5-nitrofuran-triazole conjugates were synthesized and evaluated for their antimicrobial activity against both Gram-positive and Gram-negative bacterial strains. All the compounds exhibited promising inhibition towards Gram-positive pathogenic strains, while mild inhibitory effects were observed towards Gram-negative bacterial strains. Some of the compounds 8a, 8b, 8e, 8f, 8h are most active among the series exhibiting MIC value of 1.17 μg/ml against different bacterial strains. The bactericidal activity is found to be in accordance with the bacterial growth inhibition data. Compound 8e was found to be equipotent to the standard drug Ciprofloxacin displaying MBC value of 1.17 μg/ml against the bacterial strain Bacillus subtilis. The compounds have also demonstrated promising antibacterial activity against the resistant strain MRSA and were found to be effective inhibitors of biofilm formation. The compound 8b exhibited excellent anti-biofilm activity with IC50 value as low as 0.8 μg/ml. These conjugates were also screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Compound 8e showed promising antitubercular activity with MIC value of 0.25 μg/ml. Most of these compounds are less toxic to normal mammalian cells than the widely used antibacterial drug Ciprofloxacin.

Imidazopyridinone derivatives and their use as phosphodiesterase inhibitors

A compound (Ia): wherein the variables are defined in the specification, its prodrug or a pharmaceutically acceptable salt thereof useful in the treatment of angina, hypertension etc.