96055-59-3Relevant articles and documents
A cyclopentane conformational restraint for a peptide nucleic acid: Design, asymmetric synthesis, and improved binding affinity to DNA and RNA
Myers, Michael C.,Witschi, Mark A.,Larionova, Nataliya V.,Franck, John M.,Haynes, Russell D.,Hara, Toshiaki,Grajkowski, Andrzej,Appella, Daniel H.
, p. 2695 - 2698 (2003)
(Matrix presented) A strategy to restrict the highly flexible backbone conformation of a peptide nucleic acid (PNA) by incorporation of a cyclopentane ring is proposed. An asymmetric synthesis of cyclopentane-modified PNA is reported, and its binding prop