96100-12-8

Basic information

• Product Name: 3-Methyl-5-trifluoromethylaniline
• Synonyms: 3-METHYL-5-(TRIFLUOROMETHYL)ANILINE;3-AMINO-5-METHYLBENZOTRIFLUORIDE;BENZENAMINE, 3-METHYL-5-TRIFLUOROMETHYL;3-methyl-5-thifluoromethylaniline;3-methyl-5-trifluoromethylaniline(MTA);3-Amino-5-methylbenzotrifluoride, 97+%;3-Amino-5-methylbenzotrifluoride 97%;3-Methyl-5-(trifluoromethyl)aniline, 3-Amino-5-(trifluoromethyl)toluene
• CAS NO: 96100-12-8
• Molecular Formula: C₈H₈F₃N
• Molecular Weight: 175.15
• Mol File: 96100-12-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 203.3 °C at 760 mmHg
• Flash Point: 84 °C
• Appearance: /
• Density: 1.238 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: 3-Methyl-5-trifluoromethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-5-trifluoromethylaniline(96100-12-8)
• EPA Substance Registry System: 3-Methyl-5-trifluoromethylaniline(96100-12-8)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 23-26-28-36/37/39-45
• RIDADR: 2811
• Hazardous Substances Data: 96100-12-8(Hazardous Substances Data)

Usage

General Description

3-Methyl-5-trifluoromethylaniline is a chemical compound with the molecular formula C9H10F3N. It is a derivative of aniline, with a methyl group at the 3-position and a trifluoromethyl group at the 5-position. 3-Methyl-5-trifluoromethylaniline is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized in the manufacturing of dyes and pigments. 3-Methyl-5-trifluoromethylaniline is considered to be toxic if ingested, inhaled, or absorbed through the skin, and is deemed hazardous to the environment. Therefore, proper handling and storage of this chemical is necessary to prevent any adverse effects on human health and the environment.

Upstream product

• 401-79-6 1-methyl-3-trifluoromethyl-benzene 
• 96783-80-1 1-Methyl-3-nitro-5-trifluoromethyl-benzene 
• 630125-49-4 1-bromo-3-nitro-5-(trifluoromethyl)benzene 

Relevant articles and documents

Preparation method of 3-alkyl-5-trifluoromethylaniline

The invention discloses an effective synthesis method of 3-alkyl -5-trifluoromethylaniline. The method comprises an alkylation reaction and a reduction reaction. According to the alkylation reaction,a compound II 3-bromine -5-nitro benzotrifluoride and alkyl boric acid are used as substrates and react in dioxane at 100 DEG C in a nitrogen environment under the conditions of a palladium catalyst and a potassium carbonate aqueous solution to obtain an alkylation product as shown in a structural general formula III. And reduction reaction is carried out, namely dissolving the compound III serving as a substrate in ethanol at 80 DEG C under the condition of zinc and concentrated hydrochloric acid, and reacting to obtain the 3-alkyl- 5-trifluoromethylaniline shown in the structural general formula I. The method is economical, and the substrates 3-bromine -5-nitro benzotrifluoride and alkyl boric acid reagents are very cheap; acid is not needed in the alkylation step, and environmental friendliness is achieved; the alkylation reaction yield is high, and the product I can be subjected to gram-grade preparation.

Substituted benzotrifluoride compounds as chemical intermediates and a process for their preparation

This invention pertains to two substituted benzotrifluoride compounds useful as chemical intermediates for a new class of 2-haloacetanilide herbicides and a process for making these intermediates. The process generally involves nitration and reduction of the corresponding benzotrifluoride compound.