96102-27-1

Basic information

• Product Name: TFA-aa-dC
• Synonyms: TFA-aa-dC;2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propenyl]cytidine;5-TFA-aa-dC
• CAS NO: 96102-27-1
• Molecular Formula: C14H17F3N4O5
• Molecular Weight: 378.3
• EINECS: -0
• Mol File: 96102-27-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TFA-aa-dC(CAS DataBase Reference)
• NIST Chemistry Reference: TFA-aa-dC(96102-27-1)
• EPA Substance Registry System: TFA-aa-dC(96102-27-1)

Safety Data

• Hazardous Substances Data: 96102-27-1(Hazardous Substances Data)

Usage

General Description

TFA-aa-dC, or trifluoroacetic acid-protected 2'-deoxyadenosine-5'-monophosphate (dAMP) phosphoramidite, is a chemical compound used in the field of nucleic acid synthesis. It is a derivative of deoxycytidine, which is a building block of DNA. TFA-aa-dC is often used as a protected precursor for the synthesis of DNA oligonucleotides, allowing for controlled and efficient addition of deoxycytidine to the growing DNA chain. The trifluoroacetic acid protection ensures the stability and solubility of the compound during synthesis, and can be removed after the addition of the nucleotide to the oligonucleotide chain. The use of TFA-aa-dC and similar compounds is essential in the chemical synthesis of DNA for various research and biotechnology applications.

Upstream product

• 952292-38-5 C₁₇H₃₂F₃NOSn 
• 611-53-0 5-Iodo-2'-deoxycytidine 

Relevant articles and documents

PYRAZOLE-TYPE CYANINE DYE

PROBLEM Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility. SOLUTION The invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R1 to R6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R7 to R10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2] : ????????-COOR12?????[2] (wherein R12 represents hydrogen atom, C1 to C10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: ????????-SO3R13?????[3] (wherein R13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4 may form a bivalent group with a group selected from -O- group, -S- group, -COO-group and groups represented by the general formulae [52] to [54]: (wherein R50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R1 to R11, along with the bivalent group formed by any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4, has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R1 to R11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.